Gregory M Vercellotti Selected Research

ethyl 6- (N- (2- chloro- 4- fluorophenyl)sulfamoyl)cyclohex- 1- ene- 1- carboxylate

1/2018	Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins.
1/2014	Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

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Gregory M Vercellotti Research Topics

Disease

36	Sickle Cell Anemia (Hemoglobin S Disease) 12/2023 - 05/2003
27	Inflammation (Inflammations) 12/2023 - 05/2003
19	Hemolysis 01/2023 - 08/2002
13	Hypoxia (Hypoxemia) 11/2022 - 07/2004
8	Neoplasms (Cancer) 01/2023 - 08/2008
6	Thrombosis (Thrombus) 01/2023 - 01/2006
5	Ischemia 11/2023 - 04/2010
5	Atherosclerosis 07/2010 - 08/2002
4	Sepsis (Septicemia) 01/2022 - 02/2013
4	Necrosis 01/2021 - 02/2013
4	Reperfusion Injury 11/2017 - 07/2003
3	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2023 - 01/2020
3	Hemolytic Anemia 01/2021 - 07/2003
3	Pain (Aches) 01/2020 - 07/2018
3	Acute Kidney Injury (Acute Renal Failure) 01/2019 - 02/2013
2	Thrombophilia 12/2023 - 01/2006
2	Anemia 12/2023 - 01/2018
2	Venous Thrombosis (Deep-Vein Thrombosis) 01/2023 - 01/2020
2	Iron Overload 01/2023 - 01/2021
2	Fever (Fevers) 01/2022 - 04/2020
2	Respiratory Insufficiency (Respiratory Failure) 01/2022 - 07/2018
2	Malaria 01/2021 - 01/2016
2	Hemorrhage 01/2019 - 12/2018
2	Prostatic Neoplasms (Prostate Cancer) 12/2013 - 08/2008
2	Vascular Diseases (Vascular Disease) 02/2013 - 09/2006
2	Atherosclerotic Plaque (Atheroma) 07/2010 - 03/2009
2	Vasculitis (Vasculitides) 11/2005 - 07/2003
1	Hyperalgesia 11/2023
1	Systolic Heart Failure 01/2023
1	COVID-19 01/2023
1	Heart Failure 01/2023
1	Cardiomyopathies (Cardiomyopathy) 01/2023
1	End Stage Liver Disease 01/2023
1	Bone Marrow Failure Disorders 07/2022
1	Acute Pain 01/2022
1	Edema (Dropsy) 01/2022
1	Polyarteritis Nodosa (Periarteritis Nodosa) 01/2022
1	Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) 01/2022
1	Thrombocytopenia (Thrombopenia) 01/2022
1	Macrocytic Anemia 01/2022
1	Acute Chest Syndrome 01/2021

Drug/Important Bio-Agent (IBA)

24	Heme (Haem)IBA 01/2023 - 08/2002
16	Hemoglobins (Hemoglobin)IBA 12/2023 - 08/2002
9	Heme Oxygenase-1IBA 01/2020 - 03/2006
8	IronIBA 01/2023 - 07/2003
8	HemopexinIBA 01/2022 - 01/2013
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2003
6	HaptoglobinsIBA 01/2018 - 01/2013
5	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 11/2022 - 06/2005
5	Carbon MonoxideIBA 01/2018 - 10/2009
5	NF-kappa B (NF-kB)IBA 10/2017 - 07/2004
4	Complement System Proteins (Complement)IBA 11/2023 - 01/2019
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2023 - 08/2008
4	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 11/2022 - 06/2005
4	CytokinesIBA 01/2020 - 07/2004
3	Fetal Hemoglobin (Hemoglobin F)IBA 01/2023 - 10/2017
3	Toll-Like Receptor 4IBA 01/2021 - 10/2017
3	LipopolysaccharidesIBA 01/2020 - 01/2014
3	GlobinsIBA 01/2019 - 04/2005
3	Hemin (Panhematin)FDA Link 11/2017 - 03/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2005 - 07/2003
2	Monoclonal AntibodiesIBA 11/2023 - 06/2005
2	Ferritins (Ferritin)IBA 01/2023 - 01/2013
2	Thromboplastin (Tissue Factor)IBA 01/2023 - 11/2017
2	Thrombin FDA Link 01/2023 - 01/2020
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2023 - 10/2017
2	E-SelectinIBA 11/2022 - 01/2015
2	Opioid Analgesics (Opioids)IBA 01/2022 - 07/2018
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2021 - 04/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 06/2015
2	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2020 - 01/2020
2	LigandsIBA 07/2018 - 08/2012
2	ethyl 6- (N- (2- chloro- 4- fluorophenyl)sulfamoyl)cyclohex- 1- ene- 1- carboxylateIBA 01/2018 - 01/2014
2	Hemeproteins (Heme Protein)IBA 01/2018 - 02/2013
2	Biomarkers (Surrogate Marker)IBA 11/2017 - 01/2006
2	AntioxidantsIBA 10/2017 - 09/2016
2	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 06/2017 - 01/2013
2	LipidsIBA 07/2010 - 03/2009
1	Oxygen (Dioxygen)IBA 12/2023
1	Adenosine Triphosphate (ATP)IBA 12/2023
1	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)IBA 12/2023
1	Sickle HemoglobinIBA 12/2023
1	Pyruvate KinaseIBA 12/2023
1	Hemoglobin AIBA 11/2023
1	hemoglobin AAIBA 11/2023
1	Factor XII (Hageman Factor)IBA 01/2023
1	Janus KinasesIBA 01/2023
1	GadoliniumIBA 01/2023
1	LectinsIBA 11/2022
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 07/2022
1	HLA Antigens (Human Leukocyte Antigens)IBA 07/2022
1	Rituximab (Mabthera)FDA Link 01/2022
1	SteroidsIBA 01/2022
1	ruxolitinibIBA 01/2022
1	GlucocorticoidsIBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	SelectinsIBA 01/2021

Therapy/Procedure

17	Therapeutics 01/2023 - 05/2003
3	Cell Transplantation 01/2020 - 08/2009
2	Liver Transplantation 01/2023 - 01/2006